POTENTIAL DRUG INTERACTIONS IN AN INTENSIVE CARE UNIT INSIDE MINAS GERAIS: A CROSS-SECTION STUDY

Authors

  • Lucas Henrique de Souza Teixeira n.af
  • Michele de Paula Maximo

Abstract

Drug interaction is defined as an event that a drug suffers or causes some change due to the administration of another drug, food or diagnostic resource. Patients treated by intensive care units (ICUs) make use of several therapeutic resources, including medications that can provide potential drug-drug interactions (pDDIs). Thus, the aim of this study is to determine the prevalence of pDDIs in medical prescriptions for a group of patients treated by an ICU of a private hospital in the interior of Minas Gerais. For this, a quantitative and descriptive cross-sectional study was conducted in an ICU, analyzing from one to five daily prescriptions of patients admitted from December 2019 to March 2020. Data from 57 patients were included, 36 (63%) of which were female and 21 (37%) were male, with a mean age of 70,6 years. 199 prescriptions were analyzed using the Micromedex® software, which represents an average of 3,5 prescriptions analyzed per patient. At least one pDDI was detected in prescriptions of 48 patients, with a total prevalence of 84%. Among the pDDIs found, those with major severity (55%) and fair documentation (67%) were more prevalent. There was a statistical correlation between the number of drugs and the prevalence of pDDIs (ρ = 0,784; p <0,001). The prevalence of pDDIs in the sample analyzed by this study was high. The analysis of medical prescriptions by the pharmacist can make it possible to detect pDDIs.

 

Descriptors: Drug interaction. Pharmaceutical services. Intensive care unit.

Published

30-06-2021

How to Cite

Lucas Henrique de Souza Teixeira, & Maximo, M. de P. (2021). POTENTIAL DRUG INTERACTIONS IN AN INTENSIVE CARE UNIT INSIDE MINAS GERAIS: A CROSS-SECTION STUDY. Revista Farmácia Generalista Generalist Pharmacy Journal, 3(1), 33–45. Retrieved from http://publicacoes.unifal-mg.edu.br/revistas/index.php/revistafarmaciageneralista/article/view/1442